Table 1

Histopathological diagnosis for each of the 12 English springer spaniels included in the study

PatientHistopathological diagnosis
1Hepatitis, interface, lymphocytic, plasmacytic and neutrophilic, chronic, mild, with moderate to marked hepatocyte apoptosis. Grade 1 copper
2Hepatitis, periportal, lymphocytic and neutrophilic, chronic, marked, with moderate porto-portal bridging fibrosis. Grade 2 copper
3Hepatitis, lymphocytic, plasmacytic and neutrophilic, chronic, moderate, with moderate hepatocyte apoptosis and necrosis. Grade 2 copper
4Hepatitis, interface, lymphocytic, plasmacytic and neutrophilic, chronic, severe, with mild porto-portal bridging fibrosis. Grade 2 copper
5Hepatitis, periportal, lymphocytic and neutrophilic, chronic, marked with moderate hepatocyte apoptosis and necrosis. Grade 2 copper
6Hepatitis, periportal, lymphocytic, plasmacytic and neutrophilic, chronic, marked, with mild porto-portal bridging fibrosis. Grade 1 copper
7Hepatitis, interface, lymphocytic, plasmacytic and neutrophilic, chronic, severe, with mild biliary hyperplasia and hepatocyte necrosis. Grade 2 copper
8Hepatitis, lymphocytic, plasmacytic, chronic, moderate, with moderate porto-portal bridging fibrosis. Grade 1 copper
9Hepatitis, lymphocytic, plasmacytic, chronic, moderate, with moderate portal fibrosis and portal biliary hyperplasia. Grade 1 copper
10Hepatitis, lymphocytic, plasmacytic, subacute, moderate. Grade 2 copper
11Hepatitis, lymphocytic, plasmacytic and neutrophilic, subacute, moderate, with occasional pigmented histiocytes and mild hepatocyte apoptosis. Grade 2 copper
12Hepatitis, lobular and interface, lymphocytic and neutrophilic, chronic, severe with mild portal fibrosis. Grade 1 copper