Table 2

Clinical signs documented for each of the 12 English springer spaniels reported in the study, both at enrolment and at the first recheck appointment (2–4 weeks after initiation of prednisolone therapy) with additional treatments

PatientClinical signs at diagnosisClinical signs at first recheckAdditional treatments
1Reduce appetite, vomiting, jaundiceResolution of jaundice and no abnormal clinical signs currently reported by owner.UDCA, SAMe, amoxicillin-clavulanate
2PUPDResolution of PUPD according to owner.UDCA, SAMe
3Anorexia, PUPD, vomiting, weight-loss, jaundice, lethargyJaundice still identified during clinical examination and appetite improved but reduced compared with normal. Resolution of vomiting, PUPD and lethargy according to owner, however weight-loss continued. The patient subsequently developed neurological abnormalities with worsening jaundice, and was euthanased 122 days after initiating prednisolone therapy.UDCA, SAMe, metronidazole
4Lethargy, reduced appetite, vomiting, jaundice.Jaundice not identified during clinical examination and no abnormal signs currently reported by the owner.UDCA, SAMe
5No abnormal clinical signs reported by ownerStill reported to be clinically normal by owner.UDCA, SAMe, hepatic diet
6No abnormal clinical signs reported by ownerStill reported to be clinically normal by owner.SAMe, hepatic diet
7No abnormal clinical signs reported by ownerStill reported to be clinically normal by owner.SAMe
8Jaundice, ascites, weight-lossResolution of jaundice and ascites during clinical examination. No abnormal signs currently reported by the owner. The patient subsequently developed neurological abnormalities and melaena, and was euthanased 741 days after initiating prednisolone therapy.UDCA, SAMe, spironolactone
9Reduced appetite and PUPDPUPD still present but improved, according to owner. Appetite now normal.UDCA, SAMe
10No abnormal clinical signs reported by ownerStill reported to be clinically normal by owner.
11Vomiting, lethargy, jaundice, ascites, PUPDMild PUPD and polyphagia reported by owner, otherwise no abnormal clinical signs.Hepatic diet
12Lethargy, diarrhoea, vomitingResolution of vomiting and diarrhoea but owner still reported mild lethargy.SAMe, hepatic diet, cefalexin
  • PUPD, polyuria/polydipsia; SAMe, S-adenosylmethionine; UDCA, ursodeoxycholic acid.