Clinical signs | Group | BL | Day 3 | Day 7 | Day 14 | Day 28 |

Cough | T | 6 (75%) | 6 (75%) | 4 (50%) | 4 (50%) | 0 |

C | 7 (77.8%) | 7 (77.8%) | 7 (77.8%) | 7 (77.8%) | 7 (77.8%) | |

P value | 1.000 | 1.000 | 0.335 | 0.335 | 0.002 | |

Tachypnoea | T | 4 (50%) | 3 (37.5%) | 2 (25%) | 1 (50%) | 0 |

C | 6 (66.7%) | 6 (66.7%) | 6 (66.7%) | 4 (44.4%) | 5 (55.5%) | |

P value | 0.637 | 0.346 | 0.153 | 0.294 | 0.029 | |

Pale mucous membranes | T | 2 (25%) | 2 (25%) | 1 (12.5%) | 0 | 0 |

C | 3 (33.3%) | 3 (33.3%) | 3 (33.3%) | 2 (22.2%) | 2 (22.2%) | |

P value | 1.000 | 1.000 | 0.576 | 0.470 | 0.470 | |

Reduction of food intake | T | 2 (25%) | 1 (12.5%) | 0 | 0 | 0 |

C | 1 (11.1%) | 1 (11.1%) | 1 (11.1%) | 1 (11.1%) | 1 (11.1%) | |

P value | 0.576 | 1.000 | 1.000 | 1.000 | 1.000 | |

Reduction of the activity | T | 2 (25%) | 1 (12.5%) | 1 (12.5%) | 0 | 0 |

C | 4 (44.4%) | 4 (44.4%) | 4 (44.4%) | 3 (33.3%) | 3 (33.3%) | |

P value | 0.619 | 0.294 | 0.082 | 0.206 | 0.206 | |

Oculonasal discharge | T | 1 (12.5%) | 1 (12.5%) | 1 (12.5%) | 0 | 0 |

C | 4 (44.4%) | 4 (44.4%) | 4 (44.4%) | 4 (44.4%) | 4 (44.4%) | |

P value | 0.294 | 0.294 | 0.294 | 0.082 | 0.082 | |

Adventitious breath sounds | T | 6 (75%) | 6 (75%) | 5 (62.5%) | 3 (37.5%) | 0 |

C | 8 (88.9%) | 8 (88.9%) | 8 (88.9%) | 8 (88.9%) | 7 (77.8%) | |

P value | 0.576 | 0.576 | 0.294 | 0.049 | 0.002 | |

Anaemia | T | 2 (25%) | - | - | 2 (25%) | 0 |

C | 3 (33.3%) | - | - | 1 (11.1%) | 0 | |

P value | 1.000 | 0.576 | 1.000 | |||

Inflammatory response leucogram | T | 2 (25%) | - | - | 2 (25%) | 0 |

C | 2 (22.2%) | - | - | 2 (22.2%) | 3 (33.3%) | |

P value | 1.000 | 1.000 | 0.205 | |||

Stress response leucogram | T | 1 (12.5%) | - | - | 1 (12.5%) | 2 (25%) |

C | 0 | - | - | 0 | 0 | |

P value | 0.470 | 0.470 | 0.205 | |||

Excitement response leucogram | T | 1 (12.5%) | - | - | 0 | 0 |

C | 1 (11.1%) | - | - | 0 | 0 | |

P value | 1.000 | 1.000 | 1.000 | |||

Low albumin levels | T | 3 (37.5%) | - | - | 2 (25%) | 1 (12.5%) |

C | 6 (66.7%) | - | - | 5 (55.5%) | 3 (33.3%) | |

P value | 0.346 | 0.334 | 0.576 | |||

Increased ALT/AST | T | 4 (50%) | - | - | 0 | 2 (25%) |

C | 2 (22.2%) | - | - | 1 (11.1%) | 1 (11.1%) | |

P value | 0.334 | 1.000 | 0.576 | |||

Presence of at least one radiographic sign | T | 8 (100%) | - | 8 (100%) | 5 (62.5%) | 3 (37.5%) |

C | 9 (100%) | - | 9 (100%) | 9 (100%) | 9 (100%) | |

P value | 1.000 | 1.000 | 0.082 | 0.009 |

P values are shown (Fisherâ€™s exact test). Cats of Group T=8; cats of Group C=9. Percentages in brackets. Bold values denote statistical significance.

ALT, alanine aminotransferase; AST, aspartate aminotransferase; BL, baseline.