Table 6

Data extracted from studies using the method of Tobin et al 5 for caffeine

StudynInvestigated effectsHighest dose without effectCorresponding Cplasma/serum (µg/ml)Corresponding Curine (µg/ml)
Queiroz-Neto et al 1 10Spontaneous locomotion2 mg/kg intravenously once2.3 4.87 
Savage et al 22 10Heart frequency, oxygen consumption, oxygen pulse, carbon dioxide production, time to fatigue2.5 mg/kg intravenously once3.3 5.8 
  • C, concentration; n, number of animals.