Table 7

Recorded pharmacokinetic data for theophylline

StudynDVd(p)ss ClFt ½U/P
Koppe53 64 mg/kg intravenously110858.413.611.1†
64 mg/kg orally70.50.8510.7†
Todi et al 50 21.5 g intravenously18.8†
22 g orally once daily for five days10.5†
Perez et al 54 43.5 mg/kg intravenously11005414.4
Errecalde and Landoni55 610 mg/kg intravenously13506116.91
Stevenson et al 56 41.5 g/horse intravenously16.8‡
Goetz et al 57 69.94 mg/kg intravenously78756.29.67
Ingvast-Larsson et al 58 85 mg/kg orally twice daily for 4.5 days85236.60.8717.0
Short et al 59 61 mg/kg intravenously703519.89
Ayres et al 60 610 mg/kg intravenously102054.612.4
Ingvast-Larsson et al 17 63 mg/kg intravenously102051.614.8
63 mg/kg orally100046.81.0815.3
76 mg/kg orally100038.418.7
Errecalde et al 61 615 mg/kg intravenously85340.215.22
615 mg/kg orally39.21.0815.13
310 mg/kg intravenously89736.117.2
310 mg/kg orally30.20.9120.97
Kowalczyk et al 62 69.44 mg/kg intravenously88551.711.9
Machnik et al 21 64 mg/kg intravenously126852.017.212
  • *Calculated value.

  • †Graphically determined value.

  • Cl, clearance in ml/hour x kg; D, dose; F, bioavailability;n, number of animals.t ½, terminal half-life in hours; U/P, urine–plasma concentration ratio in the steady-state or pseudo-steady-state; Vd(p)ss, volume of distribution in ml/kg in the (pseudo)-steady state.