TABLE 1:

Key components of the reviewed North Carolina State University studies

Study identifier/yearStudy typeTotal number enrolled/number in placebo groupNumber of joints with pain and radiographic evidence of degenerative joint diseaseQualifying baseline Client-Specific Outcome Measure ‘disability’ scoreStudy designAssessment time pointsComments
Diet (2009)Non-drug; double blind40/201≥7 (of 20)Diets transitioned over days 1–7. Remained on study diets for nine weeks.Days 0 and 70 (end of study)Day 0 used because it was before transition to new diet and ‘treatment’. Average activity counts over days 0–7=baseline. Activity counts during days 63–70 was comparator.
DQ (2011)Non-drug; double blind59/301≥7 (of 20)Placebo given between days 0 and 14. Placebo or active treatment given for six weeks.Days 0 and 56 (end of study)Day 0 was used since owners were blind to when treatment started. Average activity counts over days 0–14=baseline. Activity counts during days 49–56 was comparator.
FMPI (2012)Drug; double blind25/131≥7 (of 20)Two-week baseline. Placebo or active treatment given for two weeks. Two-week washout and crossover.Days 14 (baseline) and 28 (end of first treatment period)Average activity counts over days 2–13=baseline. Activity counts during days 16–27 was comparator.
Low-dose (2013)Drug; double blind58/292≤5 (of 12)Two-week baseline. Placebo or active treatment given for three weeks. Three-week washout and crossoverDays 14 (baseline) and 35 (end of first treatment period)Day 14 was the assessment just before the start of the treatment. Average activity counts over days 0–14= baseline. Activity counts during days 38–35 was comparator.
Antibody (2014)Drug; double blind34/112≤5 (of 12)Two-week baseline. Placebo or active treatment given for nine weeks.Days 14 and 35 (first assessment period following treatment)Day 14 was the assessment just before the start of the treatment. Average activity counts over days 0–14=baseline. Activity counts during days 28–35 was comparator.
  • FMPI, Feline Musculoskeletal Pain Index