STRN genotypes observed in Boxer Family line 1, line 2 and the normal disease-free section of the breed and comparison with randomly sampled Holter-tested cases and controls

Line 1 ARVC cases1013023
Line 2 ARVC cases681024
Normal (by pedigree)5161031
Holter-tested ARVC cases*514726
Normal (Holter tested)*63413
  • *Data from Dukes-McEwan and others (2010). Small sample size and different selection criteria in the two normal groups may account for the differing STRN mutation frequencies and the Hardy-Weinberg near-disequilibrium in the Holter-tested normal group (P(null)=0.057). However, there was not a statistically significant difference between the frequencies of the genotypes in the two normal groups (P=0.081). The main point is that the STRN mutation is common in both samples of normal dogs. There is a significant difference between the frequency of genotypes in lines 1 and 2 (P=0.002). However, there is no statistically significant difference in the frequency of genotypes between all ARVC cases and all normals (P=0.0597)

  • ARVC, arrhythmogenic right ventricular cardiomyopathy; HOM, homozygous for the STRN deletion mutation; HET, heterozygous for the STRN mutation; WT, wild type (normal)