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Investigation of pathological haemorrhage in Maine Coon cats
  1. Conor O'Halloran1,2,
  2. Petra Cerna1,3,
  3. Craig Breheny1,
  4. Nicki Reed4,
  5. Kerry Rolph5,
  6. Sue Cade6,
  7. Jaimie Jones6,
  8. Richard Arthur Llewellyn Brown7,
  9. Suzy Slade8,
  10. Kostas Papasouliotis9 and
  11. Danielle Gunn-Moore1,2
  1. 1Hospital for Small Animals, The Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, UK
  2. 2The Roslin Institute, University of Edinburgh, Roslin, UK
  3. 3Small Animal Clinic, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
  4. 4Veterinary Specialists, Roslin, Livingston, UK
  5. 5School of Veterinary Medicine, Ross University, Basseterre, St. Kitts, West Indies, USA
  6. 6Animal Health Trust, Newmarket, Suffolk, UK
  7. 7Strathbogie Veterinary Centre Ltd, Huntly, UK
  8. 8Brilthor Maine Coons, Huntly, UK
  9. 9Axiom Veterinary Laboratories Ltd and Finn Pathologists, Norfolk, UK
  1. Correspondence to Dr Conor O'Halloran, The Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, UK; s0903769{at}sms.ed.ac.uk

Abstract

Objective Afibrinogenaemic haemorrhage was previously reported in a Maine Coon cat. Two littermates subsequently died from surgical non-haemostasis, suggesting a hereditable coagulopathy.

Methods We prospectively recruited cats which were: a) Maine Coons with pathological haemorrhage (group 1, n=8), b) healthy familial relatives of group 1 (group 2, n=13) and c) healthy Maine Coons unrelated to groups 1 and 2 (group 3, n=12). Coagulation tests: prothrombin time, activated partial thromboplastin time and thrombin clotting time (TCT) were performed on citrated plasma along with quantification of fibrinogen. Routine haematological examination was performed on EDTA-anticoagulated blood collected contemporaneously.

Results Thirty-three blood samples were analysed. Fibrinogen concentrations were significantly reduced in groups 1 (P<0.01) and 2 (P<0.01) compared with group 3. Similarly, TCT was found to be significantly extended in group 1 (P<0.01) and group 2 (P=0.02) with respect to group 3.

Conclusions Dysfibrinogenaemia was identified in clinical cases and their healthy relatives, suggesting that this may represent a hereditary condition of Maine Coon cats. Clinicians should be aware of the increased potential for non-haemostasis in this cat breed and consider assessing clotting function before (elective) surgery.

  • Maine Coon
  • coagulopathy
  • haemorrhage
  • dysfibrinogenaemia
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Footnotes

  • CO and PC are joint first authors.

  • Funding CO’H is supported by a Biotechnology and Biological Sciences Research Council (BBSRC) studentship (BB/M014894/1).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. All data relevant to the study are included in the article or uploaded as supplementary information.

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