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Prevalence of canine primary hyperparathyroidism recurrence in Keeshond and non-Keeshond dogs after curative parathyroidectomy
  1. Dan Thompson1 and
  2. Barbara Skelly2
  1. 1Davies Veterinary Specialists, Hitchin, Hertfordshire, UK
  2. 2Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, United Kingdom
  1. Correspondence to Mr Dan Thompson, Davies Veterinary Specialists, Hitchin, SG5 3HR, UK; daniel.thompson{at}


Background Primary hyperparathyroidism (PHPT) is an uncommon condition in dogs, for which there is a documented genetic predisposition in Keeshonden and sporadic cases in other breeds. Secondary literature reports a 10 per cent prevalence for recurrence in patients successfully treated by surgical parathyroidectomy, however there is no published primary literature available on which to base this assertion. This study sought to document prevalence of recurrence within Keeshonden and non-Keeshonden breeds. The authors hypothesised that Keeshonden would have a higher rate of recurrence due to the genetic predisposition for the disease, as compared with sporadic cases in other breeds, and that Keeshonden might have an earlier age of detection of disease.

Methods A retrospective review of medical records was undertaken to assess the prevalence of recurrence, the length of time after diagnosis that the recurrence occurred, and the age of initial diagnosis in both Keeshonden and non-Keeshonden breeds.

Results The study found that Keeshonden were significantly more likely to develop recurrence (6/12, 50 per cent) than non-Keeshonden dogs (1/15, 7 per cent) (P=0.024), and were significantly younger (median 108 v 126 months, P=0.043) at initial disease detection. Recurrence in Keeshonden occurred at median 35 months after treatment.

Conclusion This suggests all dogs treated by curative parathyroidectomy for PHPT should be monitored lifelong for recurrence of disease, and that this is particularly pertinent in the Keeshond population. Earlier screening of younger, apparently healthy Keeshonden may also be advisable.

  • Keeshond
  • hyperparathyroidism
  • endocrinology
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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Ethical approval for this study was granted by the Department of Veterinary Medicine, University of Cambridge Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. Full data on client-owned animals are available on reasonable request from

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