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Adjuvant intraperitoneal ceftriaxone in the treatment of septic peritonitis in horses
  1. Juliana de Moura Alonso1,
  2. Gustavo dos Santos Rosa1,
  3. Bruna Santos2,
  4. Simony Guerra3,
  5. Márcio Ribeiro3,
  6. Marcos Jun Watanabe1,
  7. A Alves1,
  8. Celso Rodrigues1,
  9. Regina Kiomi Takahira2 and
  10. Carlos Alberto Hussni1
  1. 1Department of Veterinary Surgery and Anaesthesiology, Univ Estadual Paulista (UNESP)—School of Veterinary Medicine and Animal Science (FMVZ), Botucatu, Brazil
  2. 2Department of Veterinary Clinics, Univ Estadual Paulista (UNESP)—School of Veterinary Medicine and Animal Science (FMVZ), Botucatu, Brazil
  3. 3Department of Veterinary Hygiene and Public Health, Univ Estadual Paulista (UNESP)—School of Veterinary Medicine and Animal Science (FMVZ), Botucatu, Brazil
  1. Correspondence to Professor Carlos Alberto Hussni; carlos.hussni{at}unesp.br

Abstract

Background Intraperitoneal administration of ceftriaxone maintains therapeutic abdominal concentrations for 24 hours in healthy horses. Therefore, it is a possible treatment for septic peritonitis. The aim of this study was to evaluate the efficacy of ceftriaxone as an adjuvant treatment in horses with septic peritonitis.

Methods Twenty-six horses with clinical signs, sonography and/or laboratory findings of septic peritonitis were included. Peritoneal fluid was collected for microbiological culture and in vitro microbial sensitivity profile assessment. Daily intraperitoneal administration of ceftriaxone (25 mg/kg) was initiated with supportive and systemic antimicrobial treatment. The animals were divided into three groups: group 1—gastrointestinal tract injuries and abdominal surgery (excluding perforations/ruptures); group 2—not related to changes in the gastrointestinal tract; group 3—secondary to intestinal rupture and/or faeces contamination.

Results The mean success rate of the treatment was 77 per cent (20/26 animals), with success rates of 84.6 per cent in group 1; 87.5 per cent, group 2; and 40 per cent, group 3.

Conclusions This is the first study to report adjuvant intraperitoneal treatment ceftriaxone for septic peritonitis in horses and indicates that this treatment can successfully treat septic peritonitis in horses.

  • antimicrobials
  • cephalosporins
  • horses
  • peritoneum
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Footnotes

  • Funding This study was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo.

  • Competing interests None declared.

  • Ethics approval Ethics Committee on Animal Use (CEUA) of the School of Veterinary Medicine and Animal Science of UNESP, Brazil (protocol 53/2016).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. The present paper is part of a study that will be finished in January of 2020. Additional data will be available after the end of the study if requested.

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