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Comparison of a continuous indwelling glucometer with a point-of-care device in healthy adult horses
  1. Alexandra Cunneen,
  2. Kelly A Wood,
  3. Kylie Mathison,
  4. Aaron M Herndon and
  5. Francois R Bertin
  1. School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia
  1. Correspondence to Dr Francois R Bertin, School of Veterinary Science, The University of Queensland, Gatton, QLD 4343, Australia; f.bertin{at}uq.edu.au

Abstract

Background Blood glucose is tightly regulated in horses; however, since hypoglycaemia and hyperglycaemia are associated with poor prognosis, close monitoring is warranted. This study aimed at evaluating a continuous indwelling glucometer (CIG) by comparing performance with a point-of-care glucometer (POC).

Methods Ten horses were equipped with CIG and an intravenous catheter. Interstitial glucose concentrations were determined by CIG every 5 min at rest, during insulin-induced hypoglycaemia and dextrose-induced hyperglycaemia, and compared with blood glucose determined by POC. Glucose concentrations were compared by two-way repeated measures analysis of variance and weighted kappa with Bland-Altman plots to determine agreement between assays.

Results Horses tolerated CIG well; however, five devices had to be replaced. There were no statistically significant differences between assays at rest or during hyperglycaemia; however, during hypoglycaemia, glucose concentrations determined by CIG were significantly higher (P=0.01). The mean bias (95% limits of agreement) between assays ranged from −0.03 (−2.46 to 2.52) mmol/l (hyperglycaemia) to 0.97 (−1.23 to 3.16) mmol/l (hypoglycaemia). Assay agreement was ‘good’ with observed agreements of 87.04% (κ=0.67).

Conclusions of the study CIG has acceptable accuracy in horses as compared with POC but overestimates glucose concentrations during hypoglycaemia and requires frequent replacement, limiting its clinical application.

  • endocrinology
  • critical care
  • insulin
  • glucose
  • diagnostic testing
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Footnotes

  • Presented at The study was presented as an abstract at the 2019 Forum of the American College of Veterinary Internal Medicine, Phoenix, AZ, USA.

  • Funding This study was funded by The University of Queensland undergraduate research program.

  • Competing interests FRB has consulted for and received funding from Boehringer Ingelheim Pty Ltd for his research.

  • Ethics approval The study was approved by The University of Queensland Animal Ethics Committee (approval: SVS/101/18).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as online supplementary information. Data are available on reasonable request to the corresponding author.

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