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Neutrophilia is associated with a poorer clinical outcome in dogs with chronic hepatitis
  1. Craig R Breheny1,
  2. Ian Handel2,
  3. Stephanie Banner3,
  4. Elspeth M Milne4,
  5. Linda R Morrison4,
  6. Sionagh H Smith4,
  7. Scott Kilpatrick1,
  8. Adam Gow1 and
  9. Richard J Mellanby1
  1. 1Hospital for Small Animals, University of Edinburgh Royal Dick School of Veterinary Studies, Easter Bush, UK
  2. 2Centre for Infectious Diseases, University of Edinburgh, Edinburgh, UK
  3. 3Gordons Vets, Musselburgh, UK
  4. 4Veterinary Pathology Unit, University of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr Craig R Breheny; cbreheny{at}


Background Liver disease is a common cause of morbidity and mortality in dogs. Currently, it is challenging to prognosticate in these cases. The aim of this study was to evaluate the utility of the haematological variables in dogs with chronic hepatitis.

Methods Dogs with chronic hepatitis confirmed on histopathology had presenting haematological values retrospectively obtained and evaluated against survival time. Eighty-two dogs met the inclusion criteria and their data analysed.

Results Neutrophilic patients, with a count greater than 12×109/l, controlled for sex and age, had a shorter survival time (P≤0.01). In dogs, neutrophilia at presentation predicted a poor outcome, whereas the other haematological parameters were not prognostically informative. When the dogs were split into even quarters on the basis of their neutrophil count, those within the higher quartiles had poorer survival times. Neutrophilia was associated with a poorer survival time in comparison to those patients with a lower count.

Conclusion The relationship between neutrophils, inflammation and clinical outcome is deserving of future study in dogs with chronic hepatitis.

  • neutrophil
  • chronic hepatitis
  • liver
  • Inflammation
  • hepatopathy
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  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval This study was approved by the institute’s Veterinary Ethical Review Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request.

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