Article Text

Download PDFPDF

Controlled field study evaluating the clinical efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural cat aelurostrongylosis
  1. Paolo Emidio Crisi1,
  2. Angela Di Cesare1,
  3. Donato Traversa1,
  4. Massimo Vignoli1,
  5. Simone Morelli1,
  6. Morena Di Tommaso1,
  7. Francesca De Santis1,
  8. Fabrizio Pampurini2,
  9. Roland Schaper3 and
  10. Andrea Boari1
  1. 1Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy
  2. 2Bayer HealthCare, Milano, Italy
  3. 3Bayer Anim Hlth GmbH, Leverkusen, Germany
  1. Correspondence to Dr Paolo Emidio Crisi; pecrisi{at}


Background Aelurostrongylus abstrusus is the most important nematode affecting the respiratory tract of cats in terms of prevalence and clinical relevance. The aim of this randomised controlled field study was to confirm the efficacy of the spot-on containing emodepside/praziquantel (Profender, Bayer Animal Health) in the treatment of aelurostrongylosis.

Methods Seventeen cats with aelurostrongylosis and presenting with clinical and/or radiographic signs were included in the study. Eight cats received two biweekly doses of emodepside/praziquantel, while nine cats were allocated to a control group and received a rescue treatment at the end of the study. Clinical response was the primary outcome, while the secondary end point was the reduction of larval shedding in faeces.

Results Two weeks after the first application, the cats showed a significant, though partial, recovery of clinical signs with complete clinical and parasitological resolution. The resolution of inflammatory leucogram and a significant reduction of radiographic lesions were observed two weeks after the second treatment. Red blood cells and albumin values significantly increased after eight weeks from the second application, together with the complete regression of radiographic patterns.

Conclusion Two applications of this spot-on solution two weeks apart assured complete cessation of larval shedding and led to a complete clinical, clinicopathological and radiographic recovery.

  • aelurostrongylus abstrusus<
  • cats
  • emodepside
  • treatment
  • clinical diagnosis

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, an indication of whether changes were made, and the use is non-commercial. See:

View Full Text

Statistics from


  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests RS and FP are currently employed by Bayer Animal Health.

  • Patient consent for publication Not required.

  • Ethical statement This work involved client-owned animals only and was performed with the full informed consent of the owners or legal guardians of all animals described in this work for the procedure undertaken. All the information was derived from necessary clinical interventions and the requirements of the Italian Legislative Decree 04/03/2014 n. 26 (Implementation of the Directive 2010/63 / EU on the protection of animals used for scientific purposes) were followed. No animals or humans are identifiable within this publication, and therefore additional informed consent for publication was not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.