Article Text

Download PDFPDF
Mycobacterium avium subspecies paratuberculosis seroconversion in dairy cattle and its association with raised somatic cell count
  1. Benjamin M Barber, BVetMed (Hons) MRCVS1,
  2. Nick Bell, MA VetMB PhD PG certVet. Ed. FHEA DipECAWBM(AWSEL) MRCVS2 and
  3. Steven Van Winden, DVM MSc MBA PhD PG Cert Vet. Ed. FHEA DipECBHM MRCVS3
  1. 1 Synergy Farm Health, Evershot, UK
  2. 2 Herd Health, BOS International, Colehill, UK
  3. 3 Pathobiology and Population Sciences, Royal Veterinary College, North Mymms, UK
  1. E-mail for correspondence; svwinden{at}rvc.ac.uk

Abstract

This retrospective case–control study investigates the relationship between seroconversion to Mycobacterium avium subspecies paratuberculosis (MAP) and raised somatic cell count (SCC). The study consists of 112 case cows from three dairy farms in the UK; for each case cow with a positive antibody titre, there was a seronegative control cow for comparison. Seroconversion was monitored using milk ELISA antibody titres for MAP taken at quarterly intervals. SCCs were recorded at the time a positive antibody titre was first recorded as well as at the previous and subsequent milk recording in order to explore a temporal relationship between the two events. The previous and subsequent milk recordings were a month before and after seroconversion was identified. The results showed that cows that were infected with MAP had an increased SCC around the time that they first became seropositive, providing evidence for a temporal relationship between the two events; high SCCs were particularly prevalent before and at the time of first detecting seroconversion. The explanation is being discussed that potentially an underlying, currently not studied, factor may be predisposing both events, the progression of paratuberculosis is predisposing the host to mastitis, or indeed intramammary infections help initiate paratuberculosis progression.

  • paratuberculosis
  • subclinical mastitis
  • dairy cow
  • seroconversion
View Full Text

Statistics from Altmetric.com

Footnotes

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval Informed consent was obtained from each farmer contributing to the study. The Social Science Research and Ethical Review Board (SSRERB) of the Royal Veterinary College, University of London has examined and approved the research protocol (SR2017-1378).

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.