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Long-term outcome for two heifers with a granulosa-theca cell tumour
  1. H. Dobson, BSc, PhD, DSc, HonAssocRCVS1,
  2. M. J. Kerby, BVSc, DBR, MRCVS2,
  3. J. Chantrey, BVM&S, BSc, PhD, DipRCPath, MRCVS1 and
  4. R. F. Smith, BVSc, BSc, PhD, DipECAR, MRCVS1
  1. 1School of Veterinary Science, University of Liverpool, Leahurst, Neston, Cheshire CH64 7TE, UK
  2. 2Delaware Veterinary Group, Fulford House, Torbay Road, Castle Cary, Somerset BA7 7DT, UK
  1. E-mail for correspondence: hdobson{at}, hdobson{at}

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Granulosa-theca cell tumours (GTCTs) arise within the ovary and comprise both granulosa and theca follicular cell types. Clinical signs may progress from no abnormalities through to nymphomania, and ending with virilism. Many GTCTs are hormonally active (Bosu 1977, Meganck and others 2011), but few investigations have considered long-term prospects after surgical removal. Here, we report long-term follow-up on two heifers with GTCTs identified during pregnancy diagnosis on different farms.

Case 1 was a 20-month-old Holstein-Friesian, and ultrasonography (7.5 MHz; Easiscan, BCF Technology) revealed a small uterus, an inactive left ovary with no antral follicles, and an enlarged right ovary with several cystic-like structures but no recognisable follicles. There was no gross udder development or oedema. A blood sample was taken preoperatively and five days later. Case 2 was a 17-month-old Holstein-Friesian with an enlarged ovarian mass on the right-hand side (ultrasonography; 7.5 MHz EasiScan). Blood samples were taken twice a week for the next 13 weeks, while investigative treatments (prostaglandin F2 (PG), 2 ml Estrumate, MSD Animal Health, or gonadotrophin-releasing hormone (GnRH), 2.5 ml Receptal, MSD Animal Health) was administered, and responses were monitored on-farm.

Grossly, both masses had a lobulated surface, and measured 1585 cm, and 10106 cm, respectively. Preoperative ultrasonograms of Case 2 are presented in Fig 1. Tissue samples (1 cc) were fixed in 10 per cent formaldehyde and 5 m sections were stained with H&E. Each mass was multinodular and unencapsulated. Within the tumour, granulosa-theca …

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