Article Text

Download PDFPDF
Clinical features and long-term follow-up of 70 cases of canine idiopathic eosinophilic lung disease
  1. Domingo Casamian-Sorrosal1,
  2. Paolo Silvestrini2,
  3. Rachel Blake3,
  4. Andre Kortum4,
  5. Penny J Watson5,
  6. Yolanda Martínez3,
  7. Jordi Lopez Alvarez6,7 and
  8. Sarah Keegan8
  1. 1 Hospital Veterinario UCV y Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria y Ciencias Experimentales, Universidad Catolica de Valencia San Vicente Martir, Valencia, Spain
  2. 2 Department of Small Animal Internal Medicine, School of Veterinary Science, University of Liverpool, Neston, UK
  3. 3 University of Edinburgh, Edinburgh, UK
  4. 4 Department of Veterinary Medicine, Cambridge Veterinary School, Cambridge, UK
  5. 5 Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
  6. 6 Hospital Clinic Veterinari, Universitat Autonoma de Barcelona, Barcelona, Spain
  7. 7 Memvet Centre de Referència Veterinària, Palma de Mallorca, Spain
  8. 8 Department of Small Animal Medicine, School of Veterinary Sciences, University of Bristol, Langford, UK
  1. Correspondence to Dr Domingo Casamian-Sorrosal; domingo.casamian{at}


Background Canine idiopathic eosinophilic lung disease (ELD) is sparsely documented in the literature.

Methods Clinical presentation and outcome of dogs diagnosed with ELD (eosinophilic bronchitis or eosinophilic bronchopneumonia) were reviewed. Subgroups were made based on chronicity of clinical signs and findings of thoracic imaging: NCI (no changes in thoracic imaging), BRON (bronchial/peribronchial pattern), INT (bronchointerstitial/interstitial/alveolar).

Results Seventy cases were included. There were more young to adult, crossbreed and female dogs. Compared with the other two groups NCI dogs showed lower bronchoalveolar lavage fluid eosinophilic pleocytosis and absence of circulating eosinophilia, bronchiectasis or death due to respiratory disease. All dogs responded clinically to corticosteroids. Median treatment duration was four months. Remission (no clinical signs after treatment discontinuation for >one month) and long-term remission (>six months) was achieved in 60 per cent, and 51 per cent of patients, respectively. Relapse occurred in 26 per cent of cases after remission but was rare (3 per cent) after long-term remission. The one-year, two-year and four-year survival to death due to respiratory disease was 98 per cent, 97 per cent and 91 per cent, respectively.

Conclusion Prognosis and initial clinical response for ELD was generally good although achievement of long-term remission was only seen in 51 per cent of dogs. Different outcomes based on chronicity of signs, corticosteroid dose, thoracic imaging abnormalities and other clinical variables were not appreciated.

  • eosinophilic bronchopneumopathy
  • asthma
  • eosinophilic bronchitis
  • endoscopy
View Full Text

Statistics from


  • Presented at Preliminary results were presented as oral abstracts at the European College of Veterinary Internal Medicine 27th Annual Congress, Malta, 14–17 September 2017.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Ethical approval was obtained from the ethics board of each participating university, that is, the University of Bristol, University of Edinburgh, University of Liverpool and University of Cambridge.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available upon reasonable request, through the corresponding author.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.