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Improving lung function in asthmatic horses

A. Bessonnat, K. Picotte, J. P. Lavoie

Equine Veterinary Journal (2019)

doi: 10.1111/evj.13128

• What did the research find?

Pulmonary resistance and elastance values decreased within seven days following treatment with intra-articular triamcinolone acetonide (TA) and within 14 days following treatment with intramuscular TA. This improvement in lung function persisted up to 21 and 28 days after intra-articular and intramuscular treatment, respectively. For both routes of administration, TA serum levels peaked three days after treatment but, in most horses, fell below the detection limit of 100 pg/ml within seven days.

• How was it conducted?

Horses with severe asthma, where their asthma had been clinically exacerbated, were given either 20 mg of TA in both tarsocrural joints (n=5) or 40 mg of TA intramuscularly (n=5). Lung function and TA serum concentrations were measured before TA administration and then weekly for five weeks. TA serum concentrations were also evaluated three days after …

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