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Biomarker guided diagnosis of septic peritonitis in dogs
P. Martiny, R. Goggs
Frontiers in Veterinary Science (2019) 6
• What did the research find?
Dogs with septic peritonitis (SP) had significantly greater blood C-C motif chemokine ligand 2 (CCL2) concentrations than dogs with non-septic ascites (NSA). Dogs with SP also had significantly greater peritoneal effusion CCL2, interleukin (IL)-6, IL-10 and lactate concentrations than dogs with NSA. The most discriminant biomarker was effusion lactate, with a concentration of 4.2 mmol/l being 72.2 per cent sensitive and 84.2 per cent specific for the diagnosis of SP.
• How was it conducted?
Blood and peritoneal effusion samples were obtained from 18 dogs with SP and 19 age-matched controls. Concentrations of cell-free DNA, cytokines, glucose, lactate, N-terminal pro-C-type natriuretic peptide, nucleosomes and procalcitonin were then measured. Biomarker concentrations were compared between pairs of blood and effusion samples and between dogs with SP and those with NSA. Receiver operating characteristic curves were then generated to assess …
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