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Characterising and managing pain in dogs with osteosarcoma

B. P. Monteiro, L. de Lorimier, M. Moreau and others

PLoS ONE (2018) 13

doi: 10.1371/journal.pone.0207200

• What did the research find?

Healthy dogs had responsive conditioned pain modulation (CPM), where one stimulus inhibits the perception of a second stimulus applied to a remote area of the body, but CPM was deficient in dogs with appendicular osteosarcoma (OSA). Dogs with OSA also had a high asymmetry index. CPM in dogs with OSA improved significantly 14 days after treatment. When compared with baseline, dogs with OSA were more mobile at all time points after treatment. Except for tactile threshold and actimetry, all outcomes worsened when gabapentin was administered in addition to cimicoxib and amitriptyline.

• How was it conducted?

The pain profile of 13 client-owned dogs with OSA was compared with that of seven healthy dogs. Outcome measures included: primary and secondary mechanical thresholds (MT), CPM, stance asymmetry index, actimetry (most and least active periods) …

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