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Carnitine insufficiency linked to obesity in dogs

J. Söder, K. Höglund, J. Dicksved and others

Acta Veterinaria Scandinavica (2019) 61

doi: 10.1186/s13028-019-0446-4

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• What did the research find?

A postprandial increase in amino acid concentrations was detected in all the sampled dogs, but, in contrast with findings in people, the obese dogs did not exhibit higher concentrations than the lean dogs. Lower free carnitine concentrations were found in obese dogs compared with lean dogs. However, no effect of meal intake on plasma concentrations of carnitine was observed, despite the test food containing meat-derived carnitine precursors.

• How was it conducted?

Twenty-eight healthy male Labrador retriever dogs were included in this study. Of these 12 were classified as lean and 16 were classified as obese. Blood samples were collected after an overnight fast (14 to 17 hours). The dogs were then fed a high-fat meal, and postprandial blood samples were collected hourly for four hours. Plasma metabolites were identified using nuclear magnetic resonance, and multivariate models were used …

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