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tramadol is not an effective analgesic in chinchillas
E. Evenson, C. Mans
Journal of Exotic Pet Medicine (2019) 28, 98–104
• What did the research find?
Tramadol had no significant analgesic effect at any dose tested in this study. A significant reduction in food intake and faecal output occurred in a dose-dependent manner when tramadol was administered at 20 and 40 mg/kg, but this was self-limiting and transient. No other adverse effects were observed.
• How was it conducted?
Twelve adult chinchillas received a subcutaneous injection of either tramadol at 10, 20 or 40 mg/kg or saline at 0.4 ml/kg. Thermal antinociceptive efficacy was determined by measuring hindlimb withdrawal latencies at 0, one, two, four and eight hours after drug administration. Bodyweight, daily food intake and faecal output were measured the day before treatment and for six days after. The animals were also monitored for other adverse effects, such as neurological deficits.
• Why is it important?
Chinchillas are …
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