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Genomic investigation of porcine periweaning failure to thrive syndrome (PFTS)
  1. Francesca Bertolini1,
  2. Tianfu Yang2,
  3. Yanyun Huang3,
  4. John C S Harding4,
  5. Graham S Plastow2 and
  6. Max F Rothschild1
  1. 1 Department of Animal Science, Iowa State University, Ames, Iowa, USA
  2. 2 Livestock Gentec, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
  3. 3 Prairie Diagnostic Services Inc, Saskatoon, Saskatchewan, Canada
  4. 4 Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
  1. E-mail for correspondenceDepartment of Animal Science, Iowa State University, Ames, Iowa 50011, USA; fbert{at}


Porcine periweaning failure to thrive syndrome (PFTS) can be defined by anorexia, lethargy, progressive debilitation and compulsive behaviours that occur in seemingly healthy pigs within two to threeweeks of weaning in the absence of any known infectious, nutritional, management or environmental factors. A genetic component has been hypothesised for this syndrome. In the present study, 119 commercial pigs (80 cases and 39 controls) were genotyped with the porcine 80K single nucleotide polymorphism-chip and were analysed with logistic regression and two Fixation Index-based approaches. The analyses revealed several regions on chromosomes 1, 3, 6 and 11 with moderate divergence between cases and controls, particularly three haplotypes on SSC3 and 11. The gene-based analyses of the candidate regions revealed the presence of genes that have been reported to be associated with phenotypes like PFST including depression (PDE10A) and intestinal villous atrophy (CUL4A). It is important to increase the effort of collecting more samples to improve the power of these analyses.

  • PFTS
  • PIG
  • SNP
  • GWAS
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  • Funding This study is funded by State of Iowa, Ensminger Endowment, Iowa State University, Saskatchewan Ministry of Agriculture and Food and the Canadian Swine Health Board.

  • Competing interests None declared.

  • Ethics approval Data for this study came from previous animal studies that have been approved by the University of Saskatchewan’s Animal Research Ethics Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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