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Use of a skin substitute for the treatment of deep wounds in dogs

L. Ramio-Lluch, S. Cerrato, P. Brazis and others

Veterinary Journal (2017) 230, 36–40

doi: 10.1016/j.tvjl.2017.11.003

• What did the research find?

An autologous canine skin substitute was successfully developed and used in two dogs with large and deep skin wounds.

Large amounts of autologous bioengineered skin were able to be produced from a small skin biopsy in 12 to 14 days. The engineered skin showed a good grafting capacity and achieved complete permanent re-epithelialisation of the wound site with no signs of rejection.

• How was it conducted?

This study developed and assessed an engineered autologous skin substitute for the treatment of deep wounds in dogs.

Canine keratinocytes and fibroblasts were isolated after double enzyme digestion of biopsies from four healthy beagle dogs. Skin substitutes were constructed on a fibrin-based matrix and grafting capacity was assessed using six …

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