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Identifying biomarker for canine mammary tumours

M. Pandey, B. V. Sunil Kumar, K. Gupta and others

BMC Veterinary Research (2018) 14, 184

doi: 10.1186/s12917-018-1507-z

• What did the research find?

The study found there was significantly increased expression of mammaglobin-B protein in canine mammary tumour tissue compared to healthy mammary glands: the protein was overexpressed in 6.67 per cent of tissue from healthy mammary glands and in 76.7 per cent of canine mammary tumour tissue.

These findings suggest that overexpression of mammaglobin-B is associated with tumours of canine mammary glands.

• How was it conducted?

Biopsies from tumour-free apparently healthy mammary glands (n=30) and mammary tumour tissues (n=30) were collected from age and breed matched female dogs. Expression of mammaglobin-B mRNA and protein were assessed by quantitative real-time PCR and immunohistochemistry, respectively.

• Why is it important?

Although the exact function of the mammaglobin protein is not fully known, its expression has been reported to be upregulated in …

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