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Effect of vaccination with a porcine reproductive and respiratory syndrome subunit vaccine on sow reproductive performance in endemic farms
  1. Jiwoon Jeong1,
  2. Seeun Kim1,
  3. Changhoon Park1,
  4. Ikjae Kang1,
  5. Kee Hwan Park1,
  6. Hee Jin Ham2 and
  7. Chanhee Chae1
  1. 1 Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
  2. 2 College of Liberal Arts, Anyang University, Anyang, Republic of Korea
  1. E-mail for correspondence; swine{at}


The objective of this field study was to evaluate the reproductive performance of sows after vaccination with a porcine reproductive and respiratory syndrome (PRRS) subunit vaccine (PRRSFREE PRRS subunit vaccine, Reber Genetics, Taiwan, Republic of China) under field conditions. The study was performed in three farms with endemic infections with both PRRS virus (PRRSV)-1 and PRRSV-2, a situation representative of most Korean farms. Pregnant sows were immunised intramuscularly with 2.0 ml of the PRRS subunit vaccine at 58 and 79 days of gestation (eight and five weeks antepartum) according to the manufacturer’s recommendation. Vaccination did not result in any observed adverse reaction. Vaccinated sows exhibited a significant improvement in reproductive performance (reduction of abortions) and litter characteristics (increase of weaned pigs) compared with unvaccinated sows. Vaccinated sows had significantly (P<0.05) higher PRRSV ELISA sample/positive ratio and number of PRRSV-specific interferon-γ-secreting cells compared with the unvaccinated control group. The results of this study demonstrate that the PRRS subunit vaccine can improve the reproductive performance of sows in farms with endemic PRRSV infection.

  • porcine reproductive and respiratory syndrome (prrs)
  • reproductive failure
  • sow
  • vaccine
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  • Funding The authors’ research was supported by contract research funds (grant no 550-20160053) of the Research Institute for Veterinary Science (RIVS) from the College of Veterinary Medicine and by the BK 21 Plus Program (grant no 5260-20150100) for Creative Veterinary Science Research.

  • Competing interests None declared.

  • Ethics approval The methods used in this study were previously approved by the Seoul National University Institutional Animal Care and Use Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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