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New marker for predicting progression of Chronic Kidney Disease in dogs and cats

C. N. Chen, C. C. Chou, P. S. J. Tsai, Y. J. Lee

Veterinary Journal (2018) 232, 33-39

doi: 10.1016/j.tvjl.2017.12.011

• What did the research find?

Increased concentrations of the uraemic toxin, indoxyl sulfate, was found to be a suitable marker for predicting the progression of renal function decline in dogs and cats with chronic kidney disease (CKD).

In dogs, predicting CKD stage using indoxyl sulfate concentration was demonstrated as being superior to previously reported factors, suggesting it could replace other predictive tests used for stage 2 or 3 CKD cases in clinical practice.

• How was it conducted?

Plasma and urine samples were collected from outpatient dogs and cats with at least stage 2 CKD. Eligible animals were followed up monthly for at least three months and classified as ‘progression’ (ie, CKD progressed during the period) or ‘non-progression’ animals.

Plasma indoxyl sulphate concentrations were measured by high …

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