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Serological and phylogenetic analysis indicating prevalence of fowl adenovirus in China
  1. Jing Zhao1,
  2. Sifan Ruan1,
  3. Ye Guo2,
  4. Zirong He1,
  5. Meiyu Xu3 and
  6. Guozhong Zhang1,3
  1. 1 Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China
  2. 2 China Institute of Veterinary Drug Control, Beijing, People’s Republic of China
  3. 3 Diagnostic and Research Center of Livestock and Poultry Epidemic Diseases, China Agricultural University, Beijing, People’s Republic of China
  1. E-mail for correspondence; zhanggz{at}

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Fowl adenoviruses (FAdVs), which belong to the genus Aviadenovirus in the Adenoviridae family, are grouped into five species named Fowl adenovirus A–E (FAdV-A to FAdV-E) and 12 serotypes (1–11, 8a, 8b) based on genome sequencing and virus neutralisation, respectively. FAdVs are responsible for a wide range of clinical signs, including hydropericardium-hepatitis syndrome (HHS), inclusion body hepatitis (IBH) and gizzard erosion (GE).1 HHS is primarily caused by the FAdV-4 serotype and causes more than 30 per cent mortality.2 3 IBH is related to the multiserotype of FAdVs and leads to 10–30 per cent mortality in chickens. Some FAdV-1 strains are responsible for GE.1 3

Cases of IBH or HHS have been increasing rapidly, resulting in great economic losses worldwide.3–8 In the present study, we determined the prevalence of FAdV infections in chicken flocks in China by serological analysis and characterised the genotypic distribution among the FAdV strains previously reported in China in GenBank database by phylogenetic analysis. Our findings could provide implications for a promising control measure and vaccination strategy for FAdV infection in the poultry industry.

To evaluate the prevalence of FAdV infections in China, a total of 4544 serum samples were collected from 119 different non-vaccinated chicken flocks in 2014–2016. These samples were localised in 13 provinces or cities in …

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  • Funding This study was supported by the Beijing Agriculture Innovation Consortium of Poultry Research System (BAIC04-2017).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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