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A presumptive case of gluten sensitivity in a border terrier: a multisystem disorder?
  1. M. Lowrie, MA, VetMB, MVM, DipECVN, MRCVS1,
  2. M. Hadjivassiliou, MBCHB, MRCP, FRCP, MD2,
  3. D. S. Sanders, MD, FRCP, FACG3 and
  4. O. A. Garden, BSc, BVetMed, PhD, FHEA, MSB, DipACVIM, DipECVIM-CA4
  1. 1Dovecote Veterinary Hospital, 5 Delven Lane, Castle Donington, Derby DE74 2LJ, UK
  2. 2Department of Neurology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  3. 3Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
  4. 4Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Hertfordshire AL9 7TA, UK
  1. E-mail for correspondence: mark.lowrie{at}


Paroxysmal gluten-sensitive dyskinesia (previously termed canine epileptoid cramping syndrome) is a condition of Border terriers in which the leading manifestation is neurological. The authors describe a case they believe to represent the first report of a Border terrier with a combination of neurological signs, atopy, positive serological results for anti-transglutaminase 2 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies, and signs suggestive of gastrointestinal disease with pathological changes in the gastrointestinal tract—seemingly responsive to a gluten-free diet. As such, the authors suggest that gluten sensitivity in Border terriers may manifest as a multisystem disease in a similar manner to that seen in human beings.

  • Dyskinesia
  • Neurology
  • Dermatology
  • Inflammatory Bowel Disease
  • Atopy
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