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J. W. Angell and colleagues comment:
Sample size calculations were conducted based on our best estimates of flock size, expected disease prevalence at that time of year, and our expectations of how the intervention would perform. All these values were necessarily estimates given that there is very little accurate information available. Indeed, the one value more within our control – flock size – also proved difficult to handle; for example, one farm of ‘approximately 300 sheep’ in fact had 880 sheep when visited!
We also wanted to balance the ethical considerations of detecting a difference, if present, with the use of a large volume of critically important antibiotic. In addition, we lost more flocks to follow-up …
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