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Calf health
Cholesterol deficiency causing calf illthrift and diarrhoea
  1. J. P. Duff1,
  2. S. Passant2,
  3. M. Wessels3,
  4. C. Charlier4,
  5. G. Hateley5 and
  6. R. M. Irvine6
  1. 1Animal and Plant Health Agency (APHA) Penrith, Merrythought, Penrith CA11 9RR e-mail:
  2. 2Oakhill Veterinary Centre, Langley Lane, Goosnargh, Preston, Lancashire PR3 2JQ
  3. 3Finn Pathologists, One Eyed Lane, Weybread, Diss, Norfolk IP21 5TT
  4. 4Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège (B34), 1 Avenue de l'Hôpital, 4000-Liège (Sart Tilman), Belgium
  5. 5Veterinary lead, Cattle Expert Group, APHA Lasswade, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ
  6. 6Head of Surveillance Intelligence Unit and Scanning Surveillance Programme, APHA Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB

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WE wish to report a case of cholesterol deficiency (CD), also known as haplotype cholesterol deficiency, in a 56 kg, 19-week-old Holstein-Friesian calf. This condition, caused by a genetic defect, was reported relatively recently in German calves by Kipp and others (2015) who traced the defect to a North American bull, Maughlin Storm, born in 1991 and used extensively in the Holstein population worldwide. The authors reported that, in Germany, the affected calves developed chronic diarrhoea and illthrift, and died from three weeks to six months of age. The defect is only seen clinically in the homozygote form, and although the precise gene, or action of the genes, was (until recently) unclear it causes a fatal inability to maintain a level of blood cholesterol sufficient for …

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