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Factors affecting the prognosis for dogs with protein-losing enteropathy

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K. Nakashima, S. Hiyoshi, K. Ohno, K. Uchida, Y. Goto-Koshino, S. Maeda, S. Mizutani, A. Takeuchi, H. Tsujimoto

PROTEIN-losing enteropathy (PLE) in dogs is characterised by hypoalbuminaemia due to excessive loss of plasma proteins through the gastrointestinal mucosa. It has a poor prognosis and little information is available on the factors that affect the prognosis of this condition. This retrospective cohort study aimed to identify the prognostic factors that affect the survival of dogs with PLE.

Ninety-two dogs that were diagnosed with PLE at the Veterinary Medical Center of the University of Tokyo from April 1, 2006 to January 31, 2011 were included in the study. At the time of diagnosis, the severity of clinical signs was assessed using two previously described activity indices: the canine inflammatory bowel disease activity index (CIBDAI) and the canine enteropathy clinical activity index (CCECAI). These indices are the sum of scores for different clinical signs such as vomiting, stool consistency, weight loss and severity of pruritus. Histopathology was also performed at the time of diagnosis. Variables recorded at the time of diagnosis were analysed using a multivariate analysis to see if they affected …

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