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Does infection with Corynebacterium pseudotuberculosis interfere with TB testing in goats?
J. Bezos, C. Casal, B. Romero, E. Liandris, N. Sánchez, V. Vigo, L. Domínguez, L. de Juan
CASEOUS lymphadenitis (CLA) is a chronic infectious disease caused by Corynebacterium pseudotuberculosis. It has been suggested that, due to antigenic similarities between this bacterium and mycobacteria, infection with C pseudotuberculosis can interfere with the diagnostic testing for tuberculosis (TB). This experimental study aimed to test this hypothesis in goats.
Thirteen goats from a TB-free herd that had no history of Johne's diseases or CLA infection were selected for the study. Six animals acted as controls and seven were experimentally infected with C pseudotuberculosis.
All goats were tested on a weekly basis for evidence of CLA lesions. Before the study, the animals were tested using single and comparative intradermal tuberculin (SIT and SCIT, respectively) tests using purified protein derivatives of Mycobacterium bovis (PPD-B) and Mycobacterium avium (PPD-A), and interferon (IFN)-γ assay for the diagnosis of TB. This testing was repeated six and 12 weeks after the experimental infection. The proportions of test reactors between the two groups was compared.
Before the test, all experimentally infected animals were negative in the SIT and SCIT tests. No difference was found in the numbers of reactors detected in the SIT and SCIT tests when comparing the control and infected groups. Two goats did react …
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