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Vitamin levels in dogs with kidney disease

A. Galler, J. L. Tran, S. Krammer-Lukas, U. Höller, J. G. Thalhammer, J. Zentek, M. Willmann

VITAMIN supplements are recommended in dogs with chronic kidney disease (CKD) as it is thought that abnormal renal metabolism, inadequate dietary intake or gastrointestinal absorption, increased consumption of antioxidant vitamins, washout of water soluble vitamins or altered vitamin metabolism may lead to disturbances in vitamin homeostasis. However, data on the affects of CKD on the excretion and metabolism of vitamins in dogs are limited. This study investigated the blood vitamin levels in dogs with CKD and compared these to healthy dogs with the aim of establishing recommendations for vitamin supplementation in dogs with impaired renal function.

Nineteen dogs with CKD and 47 healthy dogs were investigated. The concentrations of retinol, retinyl esters, tocopherol, thiamine, riboflavin, pyridoxal-5'-phosphate, ascorbic acid and 25-hydroxycholecalciferol were quantified using high performance liquid chromatography, and the concentrations of cobalamin, folate, biotin and pantothenic acid were measured using microbiological techniques.

Levels of retinol, retinyl palmitate, ascorbic acid and vitamins B1, B2 and B6 were all found at higher levels in CKD dogs compared with healthy dogs. Dogs …

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