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Assessment of the sedative effects of buprenorphine administered with 20 μg/kg detomidine in horses
  1. E. J. Love, BVMS, DVA, DiplECVAA, PhD, MRCVS1,
  2. P. M. Taylor, MA, VetMB, DVA, DiplECVAA, PhD, MRCVS2,
  3. J. Murrell, BVSc, CertVA, DiplECVAA, PhD, MRCVS1,
  4. H. R. Whay, BSc, PhD1 and
  5. A. E. Waterman-Pearson, BVSc, DVA, DiplECVAA, PhD, FRCVS1
  1. Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset BS40 5DU
  2. Taylor Monroe, Ely, Cambridgeshire CB6 2TY
  1. E-mail for correspondence{at}

The aim of this randomised, observer-blinded, crossover study was to compare the effects of four treatments, administered intravenously to six horses: saline and saline; 10 µg/kg detomidine and 7.5 µg/kg buprenorphine; 20 µg/kg detomidine and 7.5 µg/kg buprenorphine; and 20 µg/kg detomidine and 10 µg/kg buprenorphine. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation and duration of sedation were investigated using a univariate general linear model with post-hoc Tukey tests (P<0.05). Increasing the dose of detomidine from 10 to 20 µg/kg increased the degree of sedation when administered with the same dose of buprenorphine (7.5 µg/kg). When administered with 20 µg/kg detomidine, increasing the dose of buprenorphine from 7.5 to 10 µg/kg did not influence the degree of sedation achieved.

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  • Provenance not commissioned; externally peer reviewed

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