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Assessment of the sedative effects of buprenorphine administered with 10 μg/kg detomidine in horses
  1. E. J. Love, BVMS, DVA, DiplECVAA, PhD, MRCVS1,
  2. P. M. Taylor, MA, VetMB, DVA, DiplECVAA, PhD, MRCVS2,
  3. J. Murrell, BVSc, CertVA, DiplECVAA, PhD, MRCVS1,
  4. H. R. Whay, BSc, PhD1 and
  5. A. E. Waterman-Pearson, BVSc, DVA, DiplECVAA, PhD, FRCVS1
  1. Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, North Somerset BS40 5DU
  2. Taylor Monroe, Ely, Cambridgeshire CB6 2TY
  1. E-mail for correspondence{at}

The aim of this randomised, observer-blinded, crossover study was to compare the effects of six treatments, administered intravenously to six horses: saline and saline (S/S); detomidine and saline (D/S); detomidine and 5 µg/kg buprenorphine (D/B5); detomidine and 7.5 µg/kg buprenorphine (D/B7.5); detomidine and 10 µg/kg buprenorphine (D/B10); and detomidine and 25 µg/kg butorphanol (D/BUT). The detomidine dose was 10 µg/kg for all treatments in which it was included. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation, duration of sedation and the area under the curve (AUC) for sedation scores were investigated using a univariate general linear model with post-hoc Tukey tests (P<0.05). Peak sedation and duration of sedation were statistically significantly different between treatments (P<0.001). No sedation was apparent after administration of S/S. The AUC was significantly different between treatments (P=0.010), with S/S being significantly different from D/S, D/BUT, D/B5 and D/B7.5, but not D/B10 (P=0.051).

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  • Provenance not commissioned; externally peer reviewed

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