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Efficacy of combined porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae vaccination in piglets
  1. C. S. Drexler, PhD1,
  2. M. H. Witvliet, PhD1,
  3. M. Raes, BSc1,
  4. M. van de Laar, BSc1,
  5. A. A. S. Eggen, DVM1 and
  6. E. L. Thacker, DVM, PhD2,3
  1. 1Intervet/Schering-Plough Animal Health, PO Box 31, 5830 AA Boxmeer, The Netherlands
  2. 2Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
  3. 3Animal Health, Agricultural Research Service, United States Department of Agriculture, 5601 Sunnyside Avenue, Beltsville, MD 20705-5148, USA
  1. E-mail for correspondence: christa.drexler{at}


Three vaccination challenge studies were performed to evaluate the impact on vaccine efficacy of combining porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae vaccines. Piglets were vaccinated with either a M hyopneumoniae bacterin, a modified live PRRSV vaccine based on a European-type PRRSV strain, or a combination of both vaccines, followed by experimental infection with either M hyopneumoniae or PRRSV. Vaccine efficacy was evaluated by assessing lung lesion scores for M hyopneumoniae and measuring viraemia for PRRSV. There were no significant differences between the protective efficacy of the combined vaccine protocol and the protective efficacy of the two single vaccines, indicating that PRRSV vaccination did not interfere with M hyopneumoniae vaccine efficacy and vice versa.

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