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Salmonella colonisation of laying hens following vaccination with killed and live attenuated commercial Salmonella vaccines
  1. R. J. Atterbury, BSc, PhD,
  2. V. M. Allen, PhD, FIBMS1,
  3. J. J. Carrique-Mas, DVM, MSc, PhD, MRCVS and
  4. R. H. Davies, BVSc, PhD, MRCVS2
  1. 1 Department of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5LX
  2. 2 Department of Bacterial Diseases, Veterinary Laboratories Agency — Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB
  1. School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, LE12 5RD robert.atterbury{at}


The aim of this study was to determine the efficacy of a killed Salmonella vaccine and three live vaccines in preventing caecal colonisation of Hy-line Brown pullets by Salmonella Enteritidis PT 4. The lowest number of Salmonella-positive birds following the largest challenge (108 cfu) was recorded for live vaccine 1. However, birds treated with the killed vaccine had a significantly lower number of salmonellae in their caeca compared with both the control group and the other vaccine groups (P<0˙05).

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