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Analysis of cerebrospinal fluid in healthy rabbits and rabbits with clinically suspected encephalitozoonosis
  1. A. Jass, DrMedVet, MRCVS1,
  2. K. Matiasek, DrMedVet2,
  3. J. Henke, DrMedVet3,
  4. H. Küchenhoff, DrStat4,
  5. K. Hartmann, DrMedVet, DipECVIM-CA1 and
  6. A. Fischer, DrMedVet, DipECVN, DipACVIM1
  1. 1 Clinic of Small Animal Medicine
  2. 2 Department of General Pathology and Neuropathology, Faculty of Veterinary Medicine, Ludwig Maximilian University Munich, Veterinaerstrasse 13, 80539 Munich, Germany
  3. 3 Centre of Preclinical Research, Ismaningerstrasse 22, 81675 Munich, Germany
  4. 4 Institute for Statistics, Ludwig Maximilian University Munich, Ludwigstrasse 33, 80539 Munich, Germany
  1. Correspondence to Dr Fischer


Samples of uncontaminated cerebrospinal fluid (csf) were collected from the cisterna magna of 20 healthy laboratory rabbits and 21 pet rabbits with vestibular disease and/or paresis due to clinically suspected encephalitozoonosis. In the healthy rabbits' csf the leucocyte count was ≤4 leucocytes/μl (median 1·5 μl) and the concentration of protein ranged from 0·13 to 0·31 g/l (median 0·24 g/l). In the diseased rabbits, the number of leucocytes ranged from 1 to 87/μl (median 15/μl; P<0·001), and the concentration of protein ranged from 0·31 to 1·54 g/l (median 0·79 g/l; P<0·001); a cytological evaluation showed that they had greater numbers of lymphocytes and monocytes. It was concluded that encephalitozoonosis in rabbits is characterised by lymphomonocytic pleocytosis in csf.

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