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Death of a horse infected experimentally with Anaplasma phagocytophilum
  1. P. Franzén, DVM1,
  2. A-L. Berg, DVM, PhD2,
  3. A. Aspan, PhD3,
  4. A. Gunnarsson, DVM, PhD3 and
  5. J. D. Pringle, VM, DVSc, PhD1
  1. 1 Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7018, S-75007 Uppsala, Sweden
  2. 2 AstraZeneca R&D Södertälje, Safety Assessment, S-15185 Södertälje, Sweden
  3. 3 Department of Bacteriology, National Veterinary Institute, S-75189 Uppsala, Sweden


A 19-year-old horse that was one of a group of six horses infected experimentally with Anaplasma phagocytophilum for a study of the pathogenesis of equine granulocytic ehrlichiosis died suddenly two days after first showing clinical signs of disease. The clinical signs and laboratory findings observed before its death were similar to all those of the other infected horses, and to previous reports of this disease. A postmortem examination revealed widespread haemorrhaging in its internal organs, and vasculitis and thrombosis in the kidneys. These changes are consistent with disseminated intravascular coagulation, which has previously been reported in human beings infected with the presumably identical agent of human granulocytic ehrlichiosis.

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