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Plasma concentrations of parathyroid hormone-related protein in dogs with potential disorders of calcium metabolism
  1. R. J. Mellanby, BSc, BVMS, DSAM, DipECVIM, MRCVS1,
  2. R. Craig, VetMB, MA, MRCVS1,
  3. H. Evans, BSc2 and
  4. M. E. Herrtage, BVSc, MA, DipECVDI, DipECVIM, DVR, DVD, DSAM, MRCVS1
  1. 1 Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES
  2. 2 Cambridge Specialist Laboratory Services Ltd, Unit C, First Floor, Peek House Business Centre, Dales Manor Business Park, Grove Road, Sawston, Cambridge CB2 4TJ
  1. Mr Mellanby's present address is Immunology Division, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP


The plasma concentrations of total calcium, ionised calcium, albumin, parathyroid hormone and parathyroid hormone-related protein (pthrp) were measured in 25 dogs with lymphoma, nine dogs with primary hyperparathyroidism and seven dogs with adenocarcinoma of the apocrine gland of the anal sac. Plasma total calcium, ionised calcium, albumin and parathyroid hormone-related protein were measured in 18 clinically normal control dogs. The concentration of pthrp was high in 12 of the 14 dogs that were hypercalcaemic because of an underlying malignancy but was within the reference range in all the control dogs, in the 17 normocalcaemic dogs with lymphoma and in the seven dogs which were hypercalcaemic because of a parathyroid adenoma.

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