Article Text

Histiocytic sarcoma of the spleen in flat-coated retrievers with regenerative anaemia and hypoproteinaemia
  1. J. Dobson, MA, DVetMed, DipECVIM, MRCVS1,
  2. E. Villiers, BVSc, CertSAM, CertVR, DipRCPath, MRCVS1,
  3. A. Roulois, DrVetMed, MRCVS1,
  4. S. Gould, BVetMed, DSAM, MRCVS1,
  5. P. Mellor, BSc, BVM&S, CertSAM, MRCVS1,
  6. T. Hoather, AIAT1 and
  7. P. Watson, MA, VetMB, CertVR, DSAM, DipECVIM, MRCVS1
  1. 1The Queen’s Veterinary School Hospital, Department of Clinical, Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES


Three flat-coated retrievers with a regenerative anaemia were examined. They were hypoproteinaemic suggesting that the anaemia might be due to blood loss, but it was not possible to identify a site of haemorrhage. All three had splenomegaly with splenic abnormalities apparent on ultrasonography. Ultimately all three animals were shown to have a histiocytic sarcoma involving the spleen and other tissues. A fourth flat-coated retriever with anaemia, hypoproteinaemia and an abdominal mass was also diagnosed with a histiocytic sarcoma of the spleen following splenectomy. It is postulated that the dogs’ anaemia was due to erythrophagocytosis, either directly by neoplastic cells or by reactive macrophages.

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