Article Text

Comparison of xylazine and medetomidine as premedicants for cats being anaesthetised with propofol-sevoflurane
  1. A. L. Selmi, DVM, MS, PhD1,
  2. G. M. Mendes, DVM2,
  3. B. T. Lins, DVM2,
  4. J. P. Figueiredo, DVM3 and
  5. G. R. Barbudo-Selmi, DVM, MS, SQSW4
  1. 1Universidade Anhembi Morumbi, Rua Conselheiro Lafaiete, 64 São Paulo, SP, 03164-110, Brazil
  2. 2Universidade Estadual Paulista, Distrito de Rubião Júnior, Botucatu, SP, 18618-000, Brazil
  3. 3Department of Veterinary Clinical Sciences, Ohio State University, 1900 Coffey Road, Columbus, OH 43210, USA
  4. 4304, Bloco G apto 107, Brasília, Distrito Federal, Brazil


The effects of premedicating cats with saline, xylazine or medetomidine before anaesthetising them with propofol-sevoflurane were compared. Twenty-four cats were randomly assigned to three groups of eight to receive either 0·25 ml of saline, 0·50 mg/kg of xylazine or 0·02 mg/kg of medetomidine intravenously, and anaesthesia was induced with propofol and maintained with sevoflurane. Medetomidine produced a greater reduction in the induction dose of propofol and fewer adverse postoperative effects than saline or xylazine. Hypoxaemia was observed after induction with propofol in the cats premedicated with saline and xylazine, but not in the cats given medetomidine. The cats treated with medetomidine and xylazine developed profound bradycardia. The blood pressure of the cats premedicated with saline and xylazine decreased, but the blood pressure of the cats premedicated with medetomidine was maintained. The cats premedicated with saline took longer to recover from anaesthesia than the other two groups.

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