Article Text

Download PDFPDF
Role of ketoprofen in the modulation of hyperalgesia associated with lameness in dairy cattle
  1. H. R. Whay, BSc, PhD1,
  2. A. J. F. Webster, MA, VetMB, PhD, MRCVS1 and
  3. A. E. Waterman-Pearson, BVSc, PhD, FRCVS1
  1. 1Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU


Forty lame dairy cows were randomly assigned to receive a course of either the non-steroidal anti-inflammatory drug ketoprofen, or sterile saline, together with conventional treatment for lameness. The effect of the ketoprofen was measured by using locomotion scoring and by testing the cows’ nociceptive threshold over a period of 28 days. The locomotion score of all the cows improved but ketoprofen had no significant effect on this change. However, in the cows that received ketoprofen the hyperalgesia associated with lameness, recorded using a nociceptive threshold test, was significantly modulated on days 3, 8 and 28 after their initial examination, drug administration and treatment of lesions.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.