A three-year-old cat with lymphadenopathy, non-regenerative anaemia and marked leucocytosis (171·3 x 109 white blood cells/l) was diagnosed with monocytic leukaemia and treated with a combination of anticancer drugs. A number of mature and immature monocyte-like cells were detected in the peripheral blood and bone marrow; they proved to be monocytic cells by cytochemical examination and an analysis of their cell surface phenotype, indicating that the cat suffered from acute myeloid leukaemia, subclassified as monocytic leukaemia (M5). Treatment with cytarabine, doxorubicin, vincristine and prednisolone greatly reduced the number of blast cells in the cat’s peripheral blood and bone marrow. The cat was in partial remission for 67 days and survived for 95 days after it was first examined.
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