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Double-blind, placebo-controlled study of the efficacy of nandrolone laurate in the treatment of dobermanns with subclinical hepatitis
  1. P. J. J. Mandigers, DVM, MVM, PhD, DECVN, DRNVA1,
  2. L. J. L. Horspool, BVMS, PhD, DECVPT, MRCVS3,
  3. T. S. G. A. M. van den Ingh, DVM, PhD, DECVP2,
  4. E. Teske, DVM, PhD, DECVIM-CA1,
  5. P. Bode, PhD4 and
  6. J. Rothuizen, DVM, PhD, DECVIM-CA1
  1. 1Department of Clinical Sciences of Companion Animals, PO Box 80154
  2. 2Department of Veterinary Pathology, PO> Box 80152, University of Utrecht, 3508 TD Utrecht, The Netherlands
  3. 3Intervet International, PO Box 31, 5830 AA Boxmeer, The Netherlands
  4. 4Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands


Twenty-one three-year-old dobermanns with subclinical hepatitis were treated with nandrolone laurate or a placebo in a double-blind trial. The dogs were scored clinically before and after four months of treatment and they were evaluated by clinical biochemistry and liver biopsies. After the treatment no significant differences were observed between the two groups in any of the clinical biochemistry values; eight of the 21 dogs had no histological evidence of hepatitis and five other dogs had improved, but there was no significant difference between the responses of the two groups.

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