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Minimum inhibitory concentrations of some antimicrobial drugs against bacteria causing uterine infections in cattle
  1. I. M. Sheldon, BVSc, PhD, DCHP, DBR, DipECAR, MRCVS1,
  2. M. Bushnell2,
  3. J. Montgomery, BSc1 and
  4. A. N. Rycroft, BSc, PhD2
  1. 1 Department of Veterinary Clinical Sciences
  2. 2 Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA


The minimum inhibitory concentrations (MICs) of oxytetracycline, cephapirin, cephapirin/mecillinam, cefquinome, ceftiofur and enrofloxacin, candidate antibiotics for the principal bacteria associated with uterine infections: Escherichia coli, Arcanobacterium pyogenes and the anaerobic bacteria Fusobacterium necrophorum and Prevotella melaninogenicus, were determined by the agar dilution method. The bacteria were isolated from animals with clinical metritis and/or endometritis. For E coli, cefquinome and enrofloxacin had the lowest MIC90 and MIC50 values (<0.06 μg/ml), and oxytetracycline and cephapirin had the highest values. For A pyogenes, oxytetracycline had the highest MIC50 value (16 μg/ml), but all the cephalosporins had values below 0.06 μg/ml. For the anaerobic bacteria, enrofloxacin and oxytetracycline had the highest MIC50 values but all the cephalosporins had values of 0.06 μg/ml or below.

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