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Assessment of the clinical and virological protection provided by a commercial inactivated bovine viral diarrhoea virus genotype 1 vaccine against a BVDV genotype 2 challenge
  1. C. Hamers, DVM, PhD1,
  2. B. Couvreur, MSc2,
  3. P. Dehan, MSc, PhD1,
  4. C. Letellier, MSc, PhD2,
  5. L. Fischer, DVM, PhD3,
  6. A. J. Brun, DVM4,
  7. P. Lewalle, MD5,
  8. C. Michaux, DVM, PhD6,
  9. P-P. Pastoret, DVM, AES1 and
  10. P. Kerkhofs, DVM, PhD2
  1. 1 Department of Infectious Disease
  2. 2 Department of Virology, Veterinary and Agrochemical Research Centre, Groeselenberg 99, B- 1 180 Brussels, Belgium
  3. 3 Discovery Research
  4. 4 Clinical Operations, Merial, 254 rue Marcel Mérieux, Lyon 69007, France
  5. 5 Laboratory of Experimental Haematology, Institut J. Bordet 121 Boulevard de Waterloo, 1000 Brussels, Belgium
  6. 6 Department of Biostatistics and Quantitative Genetics, Faculty of Veterinary Medicine, University of Liege, Boulevard de Colonster 20, B-4000 Liège, Belgium
  1. Merial, Parc Industriel de la Plaine de l'Ain, Allée des Cyprès, 01150 Saint-Vulbas, France


A new genotype of bovine viral diarrhoea virus (BvDv), designated BVDV-2, has emerged in the last decade and in recent years the prevalence of BVDV-2 strains has increased. A vaccination-challenge study was carried out to determine the cross-protective efficacy of a commercial inactivated vaccine containing a BVDV-1 strain. A group of five BVDv-free calves was vaccinated twice and a second group of five calves served as negative controls. Two months after the first vaccination, all the calves were challenged intranasally with BVDV-2 strain BVD890. The clinical signs of disease, the changes in haematological variables and the level of viraemia were significantly less in the vaccinated group.

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