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Controlling the onset of natural cryptosporidiosis in calves with paromomycin sulphate
  1. A. Grinberg, DVM1,
  2. A. Markovics, DVM, PhD2,
  3. J. Galindez, BSc3,
  4. N. Lopez-Villalobos, PhD1,
  5. A. Kosak, DVM4 and
  6. V. M. Tranquillo, DVM5
  1. 1 Institute of Veterinary Animal and Biomedical Sciences, Massey University, Private Bag 11.222, Palmerston North, New Zealand
  2. 2 Department of Parasitology
  3. 3 Dairy Farm, Kibbutz Ramot-Menashe, Israel
  4. 4 Northern Regional Veterinary Laboratory, Kimron Veterinary Institute, PO Box 12, Bet-Dagan, Israel
  5. 5 Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna ‘Bruno Ubertini’, Via Bianchi 10, Brescia, Italy


A prospective, controlled-blind field trial was conducted to evaluate the efficacy and safety of paromomycin sulphate, given for 10 days from birth, in preventing natural cryptosporidiosis in calves. In the untreated control group, oocyst shedding and diarrhoea followed the pattern that had occurred on the farm before the trial, consistent with a perinatal infection, whereas in the treated group, the prepatent period was significantly longer than in the control group (P<0.01) and oocyst shedding and diarrhoea started only after the drug was withdrawn. However, the regimen did not reduce the incidence of disease in the treated group.

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