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Discriminant value of blood and urinary corticoids for the diagnosis of scrapie in live sheep
  1. N. Picard-Hagen, PhD,DVM1,
  2. V. Gayrard, PhD1,
  3. V. Laroute, PhD1,
  4. C. Grandjean, DVM1,
  5. P. L. Toutain, PhD, DVM1,
  6. O. Andreoletti, DVM2,
  7. F. Schelcher, PhD, DVM2 and
  8. J. M. Elsen, PhD3
  1. 1 Unité Mixte de Recherche INRA-ENVT 181
  2. 2 Unité Mixte de Recherche INRA-ENVT 959, Ecole Nationale Vétérinaire de Toulouse, 23 Chemin de Capelles, 31076 Toulouse, France
  3. 3 Station INRA d'Amélioration Génétique des Ruminants, Chemin de Borde-Rouge, 31326 Castanet-Tolosan Cedex, France
  1. Unité Mixte de Recherche INRA-ENVT 181


The mean (sd) concentration of plasma 20β-dihydrocortisol in 126 scrapie.affected sheep was 5.5 (7.0) ng/ml compared with 1.1 (0.7) ng/ml in 52 healthy sheep. The mean (sd) concentration of creatinine in the urine of 93 scrapie.affected sheep was 2.43 (1.56) pg/ml compared with 0.94 (0.86) μg/mI in 49 healthy sheep and 1.10 (0.95) μg/ml in 25 sheep with other diseases. These discriminant analyses carried out on healthy and scrapie.affected sheep showed that plasma 20β-dihydrocortisol and urinary creatinine were the best predictors of the disease, and classified correctly 98 per cent of healthy sheep and 82 per cent of scrapie.affected sheep.

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