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Masking of two in vitro immunological assays for Mycobacterium bovis (BCG) in calves acutely infected with non-qctopathic bovine viral diarrhoea virus
  1. B. Charleston, BVetMed, MSc, PhD, MRCVS1,
  2. J. C. Hope, BSc, PhD1,
  3. B. V. Carr, BSc, MSc1 and
  4. C. J. Howard, BSc, PhD1
  1. 1 Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN


Acute infection of calves, previously vaccinated with bacille Calmette-Guerin (BCG), with non-cytopathic viral diarrhoea virus (BVDv) resulted in the temporary suppression of two in vitro assays used to monitor Mycobacterium bovis infection. Lymphocyte proliferation and interferon-γ production by whole blood cultures containing purified protein derivatives prepared from Mycobacterium avium (PPD-A) and M bovis (PPD-B) were markedly suppressed. The implication is that acute infections of cattle with non-cytopathic BVDV may temporarily compromise diagnostic tests for M bovis infections and result in a failure to identify cattle with tuberculosis.

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